ABSTRACT
Drug repurposing has become an effective approach to drug discovery, as it offers a new way to explore drugs. Based on the Science Citation Index Expanded (SCI-E) and Social Sciences Citation Index (SSCI) databases of the Web of Science core collection, this study presents a bibliometric analysis of drug repurposing publications from 2010 to 2020. Data were cleaned, mined, and visualized using Derwent Data Analyzer (DDA) software. An overview of the history and development trend of the number of publications, major journals, major countries, major institutions, author keywords, major contributors, and major research fields is provided. There were 2,978 publications included in the study. The findings show that the United States leads in this area of research, followed by China, the United Kingdom, and India. The Chinese Academy of Science published the most research studies, and NIH ranked first on the h-index. The Icahn School of Medicine at Mt Sinai leads in the average number of citations per study. Sci Rep, Drug Discov. Today, and Brief. Bioinform. are the three most productive journals evaluated from three separate perspectives, and pharmacology and pharmacy are unquestionably the most commonly used subject categories. Cheng, FX; Mucke, HAM; and Butte, AJ are the top 20 most prolific and influential authors. Keyword analysis shows that in recent years, most research has focused on drug discovery/drug development, COVID-19/SARS-CoV-2/coronavirus, molecular docking, virtual screening, cancer, and other research areas. The hotspots have changed in recent years, with COVID-19/SARS-CoV-2/coronavirus being the most popular topic for current drug repurposing research.
ABSTRACT
Drug repurposing has become an effective approach to drug discovery, as it offers a new way to explore drugs. Based on the Science Citation Index Expanded (SCI-E) and Social Sciences Citation Index (SSCI) databases of the Web of Science core collection, this study presents a bibliometric analysis of drug repurposing publications from 2010 to 2020. Data were cleaned, mined, and visualized using Derwent Data Analyzer (DDA) software. An overview of the history and development trend of the number of publications, major journals, major countries, major institutions, author keywords, major contributors, and major research fields is provided. There were 2,978 publications included in the study. The findings show that the United States leads in this area of research, followed by China, the United Kingdom, and India. The Chinese Academy of Science published the most research studies, and NIH ranked first on the h-index. The Icahn School of Medicine at Mt Sinai leads in the average number of citations per study. Sci Rep, Drug Discov. Today, and Brief. Bioinform. are the three most productive journals evaluated from three separate perspectives, and pharmacology and pharmacy are unquestionably the most commonly used subject categories. Cheng, FX;Mucke, HAM;and Butte, AJ are the top 20 most prolific and influential authors. Keyword analysis shows that in recent years, most research has focused on drug discovery/drug development, COVID-19/SARS-CoV-2/coronavirus, molecular docking, virtual screening, cancer, and other research areas. The hotspots have changed in recent years, with COVID-19/SARS-CoV-2/coronavirus being the most popular topic for current drug repurposing research.
ABSTRACT
OBJECTIVE: To analyze the results of viral nucleic acid tests for clinical specimens of the hospitalized patients with acute respiratory tract infection(ARTI) so as to provide guidance for prevention, diagnosis and treatment of ARTI. METHODS: Totally 479 patients with ARTI who were treated in Beijing Tongren Hospital Affiliated to Capital Medical University from Jan 1, 2017 to Jan 1, 2020 were enrolled in the study, the results of tests for 14 types of viruses(subtypes) such as FluA-H1, FluA-H3, FluB, parainfluenza virusI-IV, coronavirus OC43, 229 E, NL63, respiratory syncytial virus, human rhinovirus, human metapneumovirus and adenovirus in the clinical specimens were retrospectively collected. The isolation rates of the viruses and etiological and epidemiological characteristics of the patients with ARTI were observed and compared among the age groups and different seasons. RESULTS: A total of 259 strains of viruses were isolated from sputum, alveolar lavage fluid and nasopharyngeal swab specimens of 479 patients, with the isolation rate 54.1%(259/479). Among the 14 types of respiratory tract viruses isolated, the isolation rates of FluA-H1, FluA-H3, human rhinovirus, adenovirus and FluB were 42.1%(109/259), 19.7%(51/259), 8.9%(23/259), 6.2%(16/259) and 5.4%(14/259), respectively. The FluA-H1 was prevalent in autumn and winter, adenovirus was prevalent in summer, parainfluenza virusI was prevalent in summer, as compared with other seasons, there was significant difference(P<0.05);there was no significant difference in the isolation rates of other viruses among the seasons;there were no significant differences in the isolation rates of viruses among the age groups. CONCLUSION: There are a variety of viruses isolated from the clinical specimens of the hospitalized patients with ARTI, the influenza viruses are dominant and are prevalent in autumn and winter. The elderly patients are dominant among the hospitalized patients with the infection.